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Дата: Суббота, 15.Мар.2014, 03:53 | Сообщение # 109

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Ciclosporin (INN/BAN) (unalloyed /?sa?kl??sp?r?n/);[1] cyclosporine (USAN); cyclosporin (quondam BAN); or ciclosporin A, cyclosporine A, or cyclosporin A (continually shortened to CsA) is an immunosuppressant drug by many tolerant of in mouthpiece transplantation to proscribe rejection. It reduces the activity of the untouched methodology on interfering with the function and proliferation of T cells.[2][3] It was initially hidden from the fungus Tolypocladium inflatum (Beauveria nivea), found in a contaminate cross-section obtained in 1969 from Hardangervidda, Norway, alongside Dr. Hans Peter Frey, a Sandoz biologist.[4] Most peptides are synthesized by ribosomes, but ciclosporin is a cyclic nonribosomal peptide of 11 amino acids and contains a separate D-amino acid, which are rarely encountered in nature.[5]
Medical uses
The immunosuppressive effect of ciclosporin was discovered on 31 January 1972 via employees of Sandoz (in Novartis) in Basel, Switzerland, in a screening check-up on safe halting designed and implemented by means of Hartmann F. St?helin, M.D. The success of ciclosporin in preventing organ cold shoulder was shown in kidney transplants by R.Y. Calne and colleagues at the University of Cambridge,[6] and in liver transplants performed beside Dr. Thomas Starzl at the University of Pittsburgh Hospital. The first dogged, on 9 March 1980, was a 28-year-old woman.[7] Ciclosporin was subsequently approved for capitalize on in 1983. Since then, it has been used to taboo and prescribe for graft-versus-host reactions in bone-marrow transplantation and to prevent brush-off of kidney, centre, and liver transplants.[8]
In putting together to transplants, ciclosporin is also used in psoriasis, frigid atopic dermatitis, pyoderma gangrenosum, chronic autoimmune urticaria, and, exceptionally, in rheumatoid arthritis and correlated diseases, although it is only adapted to in severe cases. It is commonly prescribed in the US as an ophthalmic emulsion in place of the treatment of plain eyes.[8] It has been investigated for use in numerous other autoimmune disorders, and is sometimes prescribed in veterinary cases, explicitly in remotest cases of immune-mediated hemolytic anemia. Inhaled ciclosporin has been investigated to treat asthma and is being intentional as a preventive treatment suitable inveterate brush-off of the lungs. Ciclosporin has also been hardened to relieve discuss patients with sharp severe ulcerative colitis that do not feel for to treatment with steroids.[9] This drug is also used as a treatment of after or intervening uveitis with noninfective etiology. Ciclosporin is a drug currently acclimatized to experimentally treat cardiac hypertrophy[10][11] (an increase in chamber mass).
Ciclosporin has been investigated as a feasible neuroprotective agent in conditions such as traumatic perspicacity offence, and has been shown in beastlike experiments to modify perception damage associated with injury.[12] Ciclosporin blocks the formation of the mitochondrial permeability transition pore, which has been found to cause much of the damage associated with font maltreatment and neurodegenerative diseases. Ciclosporin's neuroprotective properties were word go discovered in the inappropriate 1990s when two researchers (Eskil Elmér and Hiroyuki Uchino) were conducting experiments in cubicle transplantation. An unintended verdict was that CsA was strongly neuroprotective when it crossed the blood–brain barrier.[13] This even so process of mitochondrial havoc toe the commencement of the MPT pore is implicated in making disturbing percipience injuries much worse.[14] Cyclosporine is currently in a appearance II/III (adaptive) clinical swot in Europe to adjudge its know-how to ameliorate neuronal cellular damage in upsetting genius injury. This multi-center study is being organized by NeuroVive Pharma and the European Perceptiveness Mistreatment Consortium using NeuroVive's formulation of cyclosporine called NeuroSTAT?. [15]

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Дата: Суббота, 29.Мар.2014, 10:12 | Сообщение # 110

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Дата: Пятница, 13.Мар.2015, 05:30 | Сообщение # 114

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